human EIF2S2 shRNA silencing Adenovirus

Name 
Ad-h-EIF2S2-shRNA
Cat No 
shADV-207727
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EIF2S2.

shADV-207727
Ad-h-EIF2S2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EIF2; EIF2B; EIF2beta; eIF-2-beta; eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; PPP1R67; protein phosphatase 1, regulatory subunit 67
Description (eCommerce)
Eukaryotic initiation factor 2 beta (eIF2beta) is the beta subunit of eukaryotic translation initiation factor 2 (eIF-2). eIF-2 forms a ternary complex with the 40S ribosomal subunit, GTP, and initiatior tRNA to function in the early steps of translation. The eIF-2 beta subunit catalyzes the exchange of GDP for GTP so that EIF-2 can function in another round of initiation.
Description (Vector)
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
Gene ID
8894
Gene Name (eCommerce)
eukaryotic translation initiation factor 2 subunit beta
Gene Name (Vector)
eukaryotic translation initiation factor 2 subunit beta
Gene Symbol
EIF2S2
HGNC ID
HGNC:3266
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
645
ORF Size (bp)
645 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 2 subunit 2
RefSeq ID
NM_003908
RefSeq Synonyms
NM_003908, NM_001316364, NM_001316363, BC007888, BC000934, BC000461,
Research Areas
BDNF Signaling,Gene Expression,Kinase/Phosphatase,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,Neurobiology,RNA Binding,RNA Transport,Signal Transduction,Translational Control,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Eukaryotic initiation factor 2 beta (eIF2beta) is the beta subunit of eukaryotic translation initiation factor 2 (eIF-2). eIF-2 forms a ternary complex with the 40S ribosomal subunit, GTP, and initiatior tRNA to function in the early steps of translation. The eIF-2 beta subunit catalyzes the exchange of GDP for GTP so that EIF-2 can function in another round of initiation.
UniGene ID
Hs.429180
UniProt ID (eCommerce)
P20042

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.