human EIF2A shRNA silencing Adenovirus

Name 
Ad-h-EIF2A-shRNA
Cat No 
shADV-207703
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EIF2A.

shADV-207703
Ad-h-EIF2A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF2A (eukaryotic translation initiation factor 2A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
65 kDa eukaryotic translation initiation factor 2A; CDA02; EIF-2A; eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa; MST089; MSTP004; MSTP089
Description (eCommerce)
Eukaryotic initiation factor 2A (eIF2A) directs binding of the intiator methionyl-tRNA [Met-tRNA(i)] to 40 S ribosomal subunits in a codon dependent manner. It is a 65 kDa protein that was originally believed to be the functional homolog of prokaryotic IF2. eIF2A displays functional qualities similar to eIF2 which exists as complex of 3 subunits (eIF2-alpha, beta, and gamma); however comparison of eIF2A and eIF2 has shown that these two intitiation factors also display distinct functional abilities.
Description (Vector)
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 (PubMed 12133843)).(supplied by OMIM, Mar 2008)
Gene ID
83939
Gene Name (eCommerce)
eukaryotic translation initiation factor 2A
Gene Name (Vector)
eukaryotic translation initiation factor 2A
Gene Symbol
EIF2A
HGNC ID
HGNC:3254
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1758
ORF Size (bp)
1758 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 2A
RefSeq ID
NM_032025
RefSeq Synonyms
NM_032025, NM_001319046, NM_001319045, NM_001319044, NM_001319043, BC011885,
Research Areas
Interleukin Signaling,Signal Transduction,TGF-beta Signaling,Translational Control,tRNA Binding
Research Areas (Faceted)
cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Eukaryotic initiation factor 2A (eIF2A) directs binding of the intiator methionyl-tRNA [Met-tRNA(i)] to 40 S ribosomal subunits in a codon dependent manner. It is a 65 kDa protein that was originally believed to be the functional homolog of prokaryotic IF2. eIF2A displays functional qualities similar to eIF2 which exists as complex of 3 subunits (eIF2-alpha, beta, and gamma); however comparison of eIF2A and eIF2 has shown that these two intitiation factors also display distinct functional abilities.
UniGene ID
Hs.655782
UniProt ID (eCommerce)
Q9BY44

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.