human EGLN3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EGLN3.
shADV-207665
Ad-h-EGLN3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EGLN3 (egl-9 family hypoxia inducible factor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
egl nine homolog 3; egl nine-like protein 3 isoform; HIFP4H3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD3; prolyl hydroxylase domain-containing protein 3
Description (eCommerce)
PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
Gene ID
112399
Gene Name (eCommerce)
egl-9 family hypoxia inducible factor 3
Gene Name (Vector)
egl-9 family hypoxia inducible factor 3
Gene Symbol
EGLN3
HGNC ID
HGNC:14661
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
360
ORF Size (bp)
360 bp
Protein Name (eCommerce)
Egl nine homolog 3
RefSeq ID
NM_022073
RefSeq Synonyms
NM_022073, NM_001308103, BC111057, BC105939, BC105938, BC102030, BC064924, BC010992,
Research Areas
Apoptosis,Cancer,DNA Damage/Repair,HIF-1 Signaling,Hypoxia,Kidney Cancer,Neurobiology,Signal Transduction,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
UniGene ID
Hs.135507
UniProt ID (eCommerce)
Q9H6Z9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.