human E2F1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human E2F1.
shADV-207490
Ad-h-E2F1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human E2F1 (E2F transcription factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E2F-1; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; transcription factor E2F1
Description (eCommerce)
E2F1 is a member of the E2F family of transcription factors. E2F is an activating member that binds DNA at the E2 recognition site in the promoters of genes involved in cell cycle regulation or DNA replication. E2F1 is regulated through its interaction with the pRb tumor suppressor.
Description (Vector)
E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Gene ID
1869
Gene Name (eCommerce)
E2F transcription factor 1
Gene Name (Vector)
E2F transcription factor 1
Gene Symbol
E2F1
HGNC ID
HGNC:3113
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1314
ORF Size (bp)
1314 bp
Protein Name (eCommerce)
Transcription factor E2F1
RefSeq ID
NM_005225
RefSeq Synonyms
NM_005225, BC058902, BC050369,
Research Areas
Aging,Apoptosis,Autophagy,Bladder Cancer,Brain Development,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,DNA Replication,EGFR Signaling,Gene Expression,Glioma,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,Leukemia,Lung Cancer,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,p53 Signaling,Prostate Cancer,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator,TSH Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
E2F1 is a member of the E2F family of transcription factors. E2F is an activating member that binds DNA at the E2 recognition site in the promoters of genes involved in cell cycle regulation or DNA replication. E2F1 is regulated through its interaction with the pRb tumor suppressor.
UniGene ID
Hs.654393
UniProt ID (eCommerce)
Q01094
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.