human DUSP6 shRNA silencing Adenovirus

Name
Ad-h-DUSP6-shRNA

Cat No
shADV-207437

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human DUSP6.

shADV-207437

Ad-h-DUSP6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DUSP6 (dual specificity phosphatase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HH19; MKP3; PYST1

Description (Vector)

DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

1848

Gene Name (Vector)

dual specificity phosphatase 6

Gene Symbol

DUSP6

HGNC ID

HGNC:3072

ORF Size (aa)

1146

ORF Size (bp)

1146 bp

RefSeq ID

NM_001946

RefSeq Synonyms

NM_022652, NM_001946, BC037236, BC005047, BC003562, BC003143,

Species

human

UniGene ID

Hs.298654

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.