human DUSP2 shRNA silencing Adenovirus

Name 
Ad-h-DUSP2-shRNA
Cat No 
shADV-207424
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human DUSP2.

shADV-207424
Ad-h-DUSP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DUSP2 (dual specificity phosphatase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PAC-1; PAC1
Description (Vector)
DUSP2 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
Gene ID
1844
Gene Name (Vector)
dual specificity phosphatase 2
Gene Symbol
DUSP2
HGNC ID
HGNC:3068
ORF Size (aa)
945
ORF Size (bp)
945 bp
RefSeq ID
NM_004418
RefSeq Synonyms
NM_004418, BC007771,
Species
human
UniGene ID
Hs.1183

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.