human DTX3L shRNA silencing Adenovirus

Name 
Ad-h-DTX3L-shRNA
Cat No 
shADV-207387
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DTX3L.

shADV-207387
Ad-h-DTX3L-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DTX3L (deltex E3 ubiquitin ligase 3L). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BBAP; B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; rhysin2; rhysin-2; RING-type E3 ubiquitin transferase DTX3L; RNF143
Description (eCommerce)
The c-terminal of BBAP (B-lymphoma and BAL-binding protein) is highly homologous to the DTX family of proteins and like the DTX family of proteins, functions as an E3 ubiquitin ligase. BBAP associates with BAL1 a transcription factor linked to poor outcome in diffuse large B-cell lymphoma (DLBCL). BAL1 and BBAP expression has been shown to be coregulated, and BBAP has been found to regulate the subcellular localization of BAL1.
Description (Vector)
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).(supplied by OMIM, Nov 2009)
Gene ID
151636
Gene Name (eCommerce)
deltex E3 ubiquitin ligase 3L
Gene Name (Vector)
deltex E3 ubiquitin ligase 3L
Gene Symbol
DTX3L
HGNC ID
HGNC:30323
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2223
ORF Size (bp)
2223 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase DTX3L
RefSeq ID
NM_138287
RefSeq Synonyms
NM_138287, BC060509, BC042191,
Research Areas
Antigen Processing and Presentation,DNA Damage/Repair,Histone Modification,Immunology,Notch Signaling,Signal Transduction,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
The c-terminal of BBAP (B-lymphoma and BAL-binding protein) is highly homologous to the DTX family of proteins and like the DTX family of proteins, functions as an E3 ubiquitin ligase. BBAP associates with BAL1 a transcription factor linked to poor outcome in diffuse large B-cell lymphoma (DLBCL). BAL1 and BBAP expression has been shown to be coregulated, and BBAP has been found to regulate the subcellular localization of BAL1.
UniGene ID
Hs.518201
UniProt ID (eCommerce)
Q8TDB6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.