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human DMXL2 shRNA silencing Adenovirus

Name 
Ad-h-DMXL2-shRNA
Cat No 
shADV-207112
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DMXL2.

shADV-207112
Ad-h-DMXL2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DMXL2 (Dmx like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DFNA71; dmX-like protein 2; PEPNS; rabconnectin-3; RC3
Description (eCommerce)
DMXL2 encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of DMXL2 in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660) [taken from NCBI Entrez Gene (Gene ID: 23312)].
Description (Vector)
DMXL2 encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
23312
Gene Name (eCommerce)
Dmx like 2
Gene Name (Vector)
Dmx like 2
Gene Symbol
DMXL2
HGNC ID
HGNC:2938
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
9114
ORF Size (bp)
9114 bp
Protein Name (eCommerce)
DmX-like protein 2
RefSeq ID
NM_015263
RefSeq Synonyms
NM_015263, NM_001174117, NM_001174116, BC144539, BC140781,
Research Areas
Neurobiology,Synapse
Research Areas (Faceted)
neurobiology
Species
human
Target Sentence
DMXL2 encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of DMXL2 in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660) [taken from NCBI Entrez Gene (Gene ID: 23312)].
UniGene ID
Hs.511386
UniProt ID (eCommerce)
Q8TDJ6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.