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human DGCR14 shRNA silencing Adenovirus

Name 
Ad-h-DGCR14-shRNA
Cat No 
shADV-206913
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DGCR14.

shADV-206913
Ad-h-DGCR14-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DGCR14 (DiGeorge syndrome critical region gene 14). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bis1; DGCR13; DGCR14; DGSH; DGS-H; DGSI; DGS-I; DiGeorge syndrome critical region 13; DiGeorge syndrome critical region 14; DiGeorge syndrome critical region gene 13; DiGeorge syndrome critical region gene 14; DiGeorge syndrome critical region gene DGSI; DiGeorge syndrome gene H; DiGeorge syndrome gene I; diGeorge syndrome protein H; ES2; Es2el; ESS-2; Protein DGCR13; protein DGCR14; Protein ES2; splicing factor ESS-2 homolog
Description (eCommerce)
The gene encoding DGCR14 (DiGeorge syndrome critical region gene 14) is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The DGCR14 protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus [taken from NCBI Entrez Gene (Gene ID: 8220)].
Description (Vector)
DGCR14 is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.
Gene ID
8220
Gene Name (eCommerce)
ess-2 splicing factor homolog
Gene Name (Vector)
DiGeorge syndrome critical region gene 14
Gene Symbol
DGCR14
HGNC ID
HGNC:16817
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1431
ORF Size (bp)
1431 bp
Protein Name (eCommerce)
Protein DGCR14
RefSeq ID
NM_022719
RefSeq Synonyms
NM_022719, BC006542,
Research Areas
Cell Biology,Gene Expression,mRNA Processing,mRNA Splicing,Neurobiology,Neurodevelopment,RNA Processing,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,neurobiology,developmental_biology
Species
human
Target Sentence
The gene encoding DGCR14 (DiGeorge syndrome critical region gene 14) is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The DGCR14 protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus [taken from NCBI Entrez Gene (Gene ID: 8220)].
UniGene ID
Hs.716675
UniProt ID (eCommerce)
Q96DF8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.