human DAXX shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DAXX.
shADV-206606
Ad-h-DAXX-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DAXX (death domain associated protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BING2; CENP-C binding protein; DAP6; Daxx; death domain-associated protein 6; death-associated protein 6; EAP1; ETS1-associated protein 1; fas death domain-associated protein; Fas-binding protein; hDaxx
Description (eCommerce)
Death-associated protein (DAXX) is a multifunctional protein originally identified as a FAS-interacting protein that modulates FAS-induced cell death. The involvement of DAXX in apoptosis has been difficult to understand, and its exact function in this process has only partially been elucidated. DAXX appears to also function as a transcriptional co-repressor and has been found to associate with the SNF2 chromatin-remodeling ATPase, alpha-thalassemia syndrome protein (ATRX), and modulate transcription.
Description (Vector)
DAXX encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Gene ID
1616
Gene Name (eCommerce)
death domain associated protein
Gene Name (Vector)
death domain associated protein
Gene Symbol
DAXX
HGNC ID
HGNC:2681
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2223
ORF Size (bp)
2223 bp
Protein Name (eCommerce)
Death domain-associated protein 6
RefSeq ID
NM_001350
RefSeq Synonyms
NM_001350, NM_001254717, NM_001141970, NM_001141969, BC109074, BC109073,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,CD95/FAS Signaling,Cell Cycle,Cell Division,Host-Virus Interactions,Interleukin Signaling,MAPK Signaling,Neurobiology,Neurodegeneration,p53 Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Death-associated protein (DAXX) is a multifunctional protein originally identified as a FAS-interacting protein that modulates FAS-induced cell death. The involvement of DAXX in apoptosis has been difficult to understand, and its exact function in this process has only partially been elucidated. DAXX appears to also function as a transcriptional co-repressor and has been found to associate with the SNF2 chromatin-remodeling ATPase, alpha-thalassemia syndrome protein (ATRX), and modulate transcription.
UniGene ID
Hs.336916
UniProt ID (eCommerce)
Q9UER7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.