human CYP1A2 shRNA silencing Adenovirus

Name
Ad-h-CYP1A2-shRNA

Cat No
shADV-206451

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CYP1A2.

shADV-206451

Ad-h-CYP1A2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CYP1A2 (cytochrome P450 family 1 subfamily A member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CP12; P3-450; P450(PA)

Description (Vector)

CYP1A2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Gene ID

1544

Gene Name (Vector)

cytochrome P450 family 1 subfamily A member 2

Gene Symbol

CYP1A2

HGNC ID

HGNC:2596

ORF Size (aa)

1551

ORF Size (bp)

1551 bp

RefSeq ID

NM_000761

RefSeq Synonyms

NM_000761, BC067429, BC067428, BC067427, BC067426, BC067425, BC067424,

Species

human

UniGene ID

Hs.1361

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.