human CTSD shRNA silencing Adenovirus

Name
Ad-h-CTSD-shRNA

Cat No
shADV-206267

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CTSD.

shADV-206267

Ad-h-CTSD-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CTSD (cathepsin D). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CLN10; CPSD; HEL-S-130P

Description (Vector)

CTSD encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Gene ID

1509

Gene Name (Vector)

cathepsin D

Gene Symbol

CTSD

HGNC ID

HGNC:2529

ORF Size (aa)

1239

ORF Size (bp)

1239 bp

RefSeq ID

NM_001909

RefSeq Synonyms

NM_001909, BC016320,

Species

human

UniGene ID

Hs.654447

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.