human CTBP1 shRNA silencing Adenovirus

Name 
Ad-h-CTBP1-shRNA
Cat No 
shADV-206219
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CTBP1.

shADV-206219
Ad-h-CTBP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CTBP1 (C-terminal binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BARS; brefeldin A-ribosylated substrate; CtBP1; C-terminal-binding protein 1; HADDTS
Description (eCommerce)
CTBP1 was first identified as a protein that interacted with adenovirus E1A oncoproteins. CTBP1 has been found to be a highly conserved transcriptional corepressor. CTBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Through its association with centrosomes, CTBP1 appears to also play a role in mitosis and Golgi complex organization.
Description (Vector)
CTBP1 encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Gene ID
1487
Gene Name (eCommerce)
C-terminal binding protein 1
Gene Name (Vector)
C-terminal binding protein 1
Gene Symbol
CTBP1
HGNC ID
HGNC:2494
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1290
ORF Size (bp)
1290 bp
Protein Name (eCommerce)
C-terminal-binding protein 1
RefSeq ID
NM_001328
RefSeq Synonyms
NM_001328, NM_001012614, BC098400, BC053320, BC011655,
Research Areas
Cancer,Cell Cycle,EGFR Signaling,Histone Modification,Host-Virus Interactions,Kinase/Phosphatase,Leukemia,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,infectious_disease,signal_transduction
Species
human
Target Sentence
CTBP1 was first identified as a protein that interacted with adenovirus E1A oncoproteins. CTBP1 has been found to be a highly conserved transcriptional corepressor. CTBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Through its association with centrosomes, CTBP1 appears to also play a role in mitosis and Golgi complex organization.
UniGene ID
Hs.208597
UniProt ID (eCommerce)
Q13363

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.