human CRY2 shRNA silencing Adenovirus

Name 
Ad-h-CRY2-shRNA
Cat No 
shADV-206045
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CRY2.

shADV-206045
Ad-h-CRY2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CRY2 (cryptochrome circadian clock 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2; growth-inhibiting protein 37; HCRY2; PHLL2
Description (eCommerce)
Cryptochrome 2 (Cry2) is a blue light-dependent regulator of the circadian feedback loop. It inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription and acts in conjunction with CRY1 in maintaining period length and circadian rhythmicity. Cry2 has no photolyase activity. It is capable of translocating circadian clock core proteins such as PER proteins to the nucleus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q49AN0].
Gene ID
1408
Gene Name (eCommerce)
cryptochrome circadian regulator 2
Gene Name (Vector)
cryptochrome circadian clock 2
Gene Symbol
CRY2
HGNC ID
HGNC:2385
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1386
ORF Size (bp)
1386 bp
Protein Name (eCommerce)
Cryptochrome-2
RefSeq ID
NM_021117
RefSeq Synonyms
NM_021117, NM_001127457, BC041814, BC035161,
Research Areas
DNA Damage/Repair,Mitochondrion,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
Cryptochrome 2 (Cry2) is a blue light-dependent regulator of the circadian feedback loop. It inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription and acts in conjunction with CRY1 in maintaining period length and circadian rhythmicity. Cry2 has no photolyase activity. It is capable of translocating circadian clock core proteins such as PER proteins to the nucleus [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q49AN0].
UniGene ID
Hs.532491
UniProt ID (eCommerce)
Q49AN0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.