human CRK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CRK.
shADV-206019
Ad-h-CRK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CRK (CRK proto-oncogene, adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CRKII; p38
Description (Vector)
CRK encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Gene ID
1398
Gene Name (Vector)
CRK proto-oncogene, adaptor protein
Gene Symbol
CRK
HGNC ID
HGNC:2362
ORF Size (aa)
915
ORF Size (bp)
915 bp
RefSeq ID
NM_005206
RefSeq Synonyms
NM_016823, NM_005206, BC009837, BC008506, BC001718,
Species
human
UniGene ID
Hs.638121
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.