human COX15 shRNA silencing Adenovirus

Name
Ad-h-COX15-shRNA

Cat No
shADV-205814

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human COX15.

shADV-205814

Ad-h-COX15-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human COX15 (COX15, cytochrome c oxidase assembly homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CEMCOX2

Description (Vector)

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region.

Gene ID

1355

Gene Name (Vector)

COX15, cytochrome c oxidase assembly homolog

Gene Symbol

COX15

HGNC ID

HGNC:2263

ORF Size (aa)

1233

ORF Size (bp)

1233 bp

RefSeq ID

NM_004376

RefSeq Synonyms

NM_078470, NM_004376, NM_001320976, NM_001320975, NM_001320974, BC078161, BC013403, BC002382,

Species

human

UniGene ID

Hs.28326

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.