human COL6A3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human COL6A3.
shADV-205715
Ad-h-COL6A3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human COL6A3 (collagen type VI alpha 3 chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BTHLM1; DYT27; UCMD1
Description (Vector)
COL6A3 encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described.
Gene ID
1293
Gene Name (Vector)
collagen type VI alpha 3 chain
Gene Symbol
COL6A3
HGNC ID
HGNC:2213
ORF Size (aa)
7713
ORF Size (bp)
7713 bp
RefSeq ID
NM_004369
RefSeq Synonyms
NM_057167, NM_057166, NM_057165, NM_057164, NM_004369, BC172233, BC171790, BC150625, BC144595,
Species
human
UniGene ID
Hs.233240
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.