human CLDN1 shRNA silencing Adenovirus

Name 
Ad-h-CLDN1-shRNA
Cat No 
shADV-205362
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CLDN1.

shADV-205362
Ad-h-CLDN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CLDN1 (claudin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
claudin-1; CLD1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
Description (eCommerce)
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. Claudin-1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95832].
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Gene ID
9076
Gene Name (eCommerce)
claudin 1
Gene Name (Vector)
claudin 1
Gene Symbol
CLDN1
HGNC ID
HGNC:2032
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
636
Protein Name (eCommerce)
Claudin-1
RefSeq ID
NM_021101
RefSeq Synonyms
NM_021101, BC012471,
Research Areas
Host-Virus Interactions,Immunology
Research Areas (Faceted)
infectious_disease,immunology
Species
human
Target Sentence
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. Claudin-1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95832].
UniGene ID
Hs.439060
UniProt ID (eCommerce)
O95832

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.