human CIITA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CIITA.
shADV-205283
Ad-h-CIITA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CIITA (class II major histocompatibility complex transactivator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C2TA; CIITAIV; MHC2TA; NLRA
Description (Vector)
CIITA encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
Gene ID
4261
Gene Name (Vector)
class II major histocompatibility complex transactivator
Gene Symbol
CIITA
HGNC ID
HGNC:7067
ORF Size (aa)
3393
ORF Size (bp)
3393 bp
RefSeq ID
NM_000246
RefSeq Synonyms
NM_001286403, NM_001286402, NM_000246, BC172348,
Species
human
UniGene ID
Hs.701991
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.