human CHUK shRNA silencing Adenovirus

Name
Ad-h-CHUK-shRNA

Cat No
shADV-205262

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CHUK.

shADV-205262

Ad-h-CHUK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CHUK (conserved helix-loop-helix ubiquitous kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Conserved helix-loop-helix ubiquitous kinase; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkB kinase alpha subunit; IKBKA; IKK1; IKKA; IKK-A; IKK-a kinase; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; TCF16; TCF-16; transcription factor 16

Description (eCommerce)

I kappa-B kinase-alpha (IKK-alpha) is part of the IKK complex composed of two regulatory subunits, IKK-alpha and IKK-beta, and a regulatory subunit, IKK-gamma/NEMO. The IKK complex functions to phosphorylate and inactivate I kappa B, an inhibitor of the NF-kappa B transcription factor.

Description (Vector)

CHUK encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Gene ID

1147

Gene Name (eCommerce)

conserved helix-loop-helix ubiquitous kinase

Gene Name (Vector)

conserved helix-loop-helix ubiquitous kinase

Gene Symbol

CHUK

HGNC ID

HGNC:1974

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2238

ORF Size (bp)

2238 bp

Protein Name (eCommerce)

Inhibitor of nuclear factor kappa-B kinase subunit alpha

RefSeq ID

NM_001278

RefSeq Synonyms

NM_001320928, NM_001278, BC092514,

Research Areas

Apoptosis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,TWEAK Signaling,VEGF Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

Species

human

Target Sentence

UniGene ID

Hs.198998

UniProt ID (eCommerce)

O15111

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.