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human CHD1 shRNA silencing Adenovirus

Name 
Ad-h-CHD1-shRNA
Cat No 
shADV-205110
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CHD1.

shADV-205110
Ad-h-CHD1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CHD1 (chromodomain helicase DNA binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATP-dependent helicase CHD1; CHD-1; chromodomain-helicase-DNA-binding protein 1; PILBOS
Description (eCommerce)
CHD1 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD1 has been shown to interact with the transcriptional corepressor NCoR and histone deacetylase 1 indicating a role in transcriptional regulation. CHD1 has also been shown to interact with the Paf1 complex and Rtf1 implicating an additional role in transcriptional elongation.
Description (Vector)
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.
Gene ID
1105
Gene Name (eCommerce)
chromodomain helicase DNA binding protein 1
Gene Name (Vector)
chromodomain helicase DNA binding protein 1
Gene Symbol
CHD1
HGNC ID
HGNC:1915
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5130
ORF Size (bp)
5130 bp
Protein Name (eCommerce)
Chromodomain-helicase-DNA-binding protein 1
RefSeq ID
NM_001270
RefSeq Synonyms
NM_001270, BC117134,
Research Areas
Chromatin Remodeling,Helicase Activity,Immunology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation,immunology,genetics
Species
human
Target Sentence
CHD1 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD1 has been shown to interact with the transcriptional corepressor NCoR and histone deacetylase 1 indicating a role in transcriptional regulation. CHD1 has also been shown to interact with the Paf1 complex and Rtf1 implicating an additional role in transcriptional elongation.
UniGene ID
Hs.643465
UniProt ID (eCommerce)
O14646

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.