human CHAT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CHAT.
shADV-205097
Ad-h-CHAT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CHAT (choline O-acetyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHOACTASE; CMS1A; CMS1A2; CMS6
Description (Vector)
CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
Gene ID
1103
Gene Name (Vector)
choline O-acetyltransferase
Gene Symbol
CHAT
HGNC ID
HGNC:1912
ORF Size (aa)
1893
ORF Size (bp)
1893 bp
RefSeq ID
NM_020549
RefSeq Synonyms
NM_020986, NM_020985, NM_020984, NM_020549, NM_001142934, NM_001142933, NM_001142929, BC130617, BC130615,
Species
human
UniGene ID
Hs.302002
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.