human CFI shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CFI.
shADV-205051
Ad-h-CFI-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CFI (complement factor I). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Description (Vector)
CFI encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.
Gene ID
3426
Gene Name (Vector)
complement factor I
Gene Symbol
CFI
HGNC ID
HGNC:5394
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_000204
RefSeq Synonyms
NM_001331035, NM_001318057, NM_000204, BC020718,
Species
human
UniGene ID
Hs.312485
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.