human CDKN1C shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CDKN1C.
shADV-204879
Ad-h-CDKN1C-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CDKN1C (cyclin dependent kinase inhibitor 1C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BWCR; BWS; cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); cyclin-dependent kinase inhibitor p57; KIP2; p57; p57Kip2; WBS
Description (eCommerce)
p57kip2 is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate [taken from NCBI GeneID:1028].
Description (Vector)
CDKN1C is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
1028
Gene Name (eCommerce)
cyclin dependent kinase inhibitor 1C
Gene Name (Vector)
cyclin dependent kinase inhibitor 1C
Gene Symbol
CDKN1C
HGNC ID
HGNC:1786
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
951
ORF Size (bp)
951 bp
Protein Name (eCommerce)
Cyclin-dependent kinase inhibitor 1C
RefSeq ID
NM_000076
RefSeq Synonyms
NM_001122631, NM_001122630, NM_000076, BC067842,
Research Areas
Cancer,Cell Cycle,Hedgehog Signaling,Immunology,Neurobiology,Neurodevelopment,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
p57kip2 is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate [taken from NCBI GeneID:1028].
UniGene ID
Hs.106070
UniProt ID (eCommerce)
P49918
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.