human CDC7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CDC7.
shADV-204780
Ad-h-CDC7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CDC7 (cell division cycle 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7L1; CDC7-related kinase; cell division cycle 7 homolog; cell division cycle 7-like protein 1; cell division cycle 7-related protein kinase; epididymis secretory sperm binding protein; HsCDC7; Hsk1; huCDC7
Description (eCommerce)
Cell division cycle 7-related protein kinase 7 (CDC7) is critical for the activation and firing of replication origins during S-phase. Cdc7 kinase activity is activated and regulated by Dbf4. Substrates of CDC7 include the MCM (mini-chromosome maintenance) proteins, DNA polymerase alpha, Cdc45, Orc4, geminin and SV40 T-antigen. CDC7 has also been implicated to play a role in the DNA damage response. Alternative names for CDC7 include;CDC7L1, hsCDC7, huCDC7, and Hsk1.
Description (Vector)
CDC7 encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
Gene ID
8317
Gene Name (eCommerce)
cell division cycle 7
Gene Name (Vector)
cell division cycle 7
Gene Symbol
CDC7
HGNC ID
HGNC:1745
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1725
ORF Size (bp)
1725 bp
Protein Name (eCommerce)
Cell division cycle 7-related protein kinase
RefSeq ID
NM_003503
RefSeq Synonyms
NM_003503, NM_001134420, NM_001134419, BC111044, BC110527, BC110526,
Research Areas
Cell Cycle,Cell Division,DNA Replication,EPO Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Replication,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,immunology,cell_biology,cell_cycle,signal_transduction
Species
human
Target Sentence
Cell division cycle 7-related protein kinase 7 (CDC7) is critical for the activation and firing of replication origins during S-phase. Cdc7 kinase activity is activated and regulated by Dbf4. Substrates of CDC7 include the MCM (mini-chromosome maintenance) proteins, DNA polymerase alpha, Cdc45, Orc4, geminin and SV40 T-antigen. CDC7 has also been implicated to play a role in the DNA damage response. Alternative names for CDC7 include;CDC7L1, hsCDC7, huCDC7, and Hsk1.
UniGene ID
Hs.533573
UniProt ID (eCommerce)
O00311
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.