human CDC2 shRNA silencing Adenovirus

Name 
Ad-h-CDC2-shRNA
Cat No 
shADV-204720
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CDK1.

shADV-204720
Ad-h-CDC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDK1 (cyclin dependent kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDC2; CDC28A; CDK1; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase; P34CDC2
Description (eCommerce)
Cyclin-dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family. CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of CKD1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control [taken from NCBI Entrez Gene (Gene ID: 983)].
Description (Vector)
CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
983
Gene Name (eCommerce)
cyclin dependent kinase 1
Gene Name (Vector)
cyclin dependent kinase 1
Gene Symbol
CDK1
HGNC ID
HGNC:1722
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
678
ORF Size (bp)
678 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 1
RefSeq ID
NM_001786
RefSeq Synonyms
NM_033379, NM_001786, NM_001320918, NM_001170407, NM_001170406, BC107750, BC014563,
Research Areas
Aging,Apoptosis,Axon Guidance,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cell Division,Cytokine Signaling,Cytoskeleton,DNA Damage/Repair,DNA Replication,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Golgi Apparatus,GPCR Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Meiosis,Mitochondrion,Neurobiology,NGF Signaling,p53 Signaling,PDGF Signaling,PLK1 Signaling,Prostate Cancer,Replication,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Toll-like Receptor Signaling,VEGF Signaling,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Cyclin-dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family. CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of CKD1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control [taken from NCBI Entrez Gene (Gene ID: 983)].
UniGene ID
Hs.334562
UniProt ID (eCommerce)
P06493

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.