human CD46 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD46.
shADV-204657
Ad-h-CD46-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD46 (CD46 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AHUS2; MCP; MIC10; TLX; TRA2.10
Description (Vector)
CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
4179
Gene Name (Vector)
CD46 molecule
Gene Symbol
CD46
HGNC ID
HGNC:6953
ORF Size (aa)
1155
ORF Size (bp)
1155 bp
RefSeq ID
NM_002389
RefSeq Synonyms
NM_172361, NM_172359, NM_172353, NM_172352, NM_172351, NM_172350, NM_153826, NM_002389, BC030594,
Species
human
UniGene ID
Hs.510402
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.