human CD38 shRNA silencing Adenovirus

Name 
Ad-h-CD38-shRNA
Cat No 
shADV-204644
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CD38.

shADV-204644
Ad-h-CD38-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CD38 (CD38 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD antigen CD38; CD38 antigen (p45); cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; T10
Description (eCommerce)
CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1) is a type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. The functional CD38 molecule is a dimer, with the central portion containing the catalytic site. CD38 is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [taken from NCBI Entrez Gene (Gene ID: 952)].
Description (Vector)
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
Gene ID
952
Gene Name (eCommerce)
CD38 molecule
Gene Name (Vector)
CD38 molecule
Gene Symbol
CD38
HGNC ID
HGNC:1667
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
903
ORF Size (bp)
903 bp
Protein Name (eCommerce)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
RefSeq ID
NM_001775
RefSeq Synonyms
NM_001775, BC007964,
Research Areas
Apoptosis,B-cell Receptor Signaling,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1) is a type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. The functional CD38 molecule is a dimer, with the central portion containing the catalytic site. CD38 is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [taken from NCBI Entrez Gene (Gene ID: 952)].
UniGene ID
Hs.479214
UniProt ID (eCommerce)
P28907

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.