human CD274 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD274.
shADV-204618
Ad-h-CD274-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD274 (CD274 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B7 homolog 1; B7-H; B7H1; B7-H1; CD antigen CD274; CD274 antigen; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1; Programmed death ligand 1
Description (eCommerce)
PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
Gene ID
29126
Gene Name (eCommerce)
CD274 molecule
Gene Name (Vector)
CD274 molecule
Gene Symbol
CD274
HGNC ID
HGNC:17635
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
873
ORF Size (bp)
873 bp
Protein Name (eCommerce)
Programmed cell death 1 ligand 1
RefSeq ID
NM_014143
RefSeq Synonyms
NM_014143, NM_001314029, NM_001267706, BC113736, BC113734, BC074984, BC069381,
Research Areas
Immune Cells and Tumor Markers,Immune-checkpoints,Immunology,Immuno-Oncology,Signal Transduction
Research Areas (Faceted)
immunology,immuno_oncology,signal_transduction
Species
human
Target Sentence
PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
UniGene ID
Hs.521989
UniProt ID (eCommerce)
Q9NZQ7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.