human CD163 shRNA silencing Adenovirus

Name 
Ad-h-CD163-shRNA
Cat No 
shADV-204580
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CD163.

shADV-204580
Ad-h-CD163-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CD163 (CD163 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD163; hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130
Description (eCommerce)
CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. CD163 functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. CD163 may also function as an innate immune sensor for bacteria and inducer of local inflammation. [taken from NCBI Entrez Gene (Gene ID: 9332)].
Description (Vector)
CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
9332
Gene Name (eCommerce)
CD163 molecule
Gene Name (Vector)
CD163 molecule
Gene Symbol
CD163
HGNC ID
HGNC:1631
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3471
ORF Size (bp)
3471 bp
Protein Name (eCommerce)
Scavenger receptor cysteine-rich type 1 protein M130
RefSeq ID
NM_004244
RefSeq Synonyms
NM_203416, NM_004244, BC051281,
Research Areas
Immunology,Signal Transduction,TWEAK Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. CD163 functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. CD163 may also function as an innate immune sensor for bacteria and inducer of local inflammation. [taken from NCBI Entrez Gene (Gene ID: 9332)].
UniGene ID
Hs.504641
UniProt ID (eCommerce)
Q86VB7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.