human CCT3 shRNA silencing Adenovirus

Name 
Ad-h-CCT3-shRNA
Cat No 
shADV-204557
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CCT3.

shADV-204557
Ad-h-CCT3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CCT3 (chaperonin containing TCP1 subunit 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CCTG; CCT-gamma; chaperonin containing TCP1, subunit 3 (gamma); hTRiC5; PIG48; T-complex protein 1 subunit gamma; T-complex protein 1, gamma subunit; TCP1 (t-complex-1) ring complex, polypeptide 5; TCP-1-gamma; TRIC5
Description (eCommerce)
CCT3 is also known as T complex protein 1 subunit gamma (TCP1-gamma) and is a molecular chaperone that assists in the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex, CCT3 may play a role in the assembly of BBSome, a complex involved in ciliogenesis and regulating the transport of vesicles to the cilia. CCT3 is known to play a role, in vitro, in the folding of actin and tubulin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P49368].
Description (Vector)
CCT3 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8.
Gene ID
7203
Gene Name (eCommerce)
chaperonin containing TCP1 subunit 3
Gene Name (Vector)
chaperonin containing TCP1 subunit 3
Gene Symbol
CCT3
HGNC ID
HGNC:1616
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1638
ORF Size (bp)
1638 bp
Protein Name (eCommerce)
T-complex protein 1 subunit gamma
RefSeq ID
NM_005998
RefSeq Synonyms
NM_005998, NM_001008800, BC008019, BC006501,
Research Areas
Cytoskeleton,Metabolism/Metabolic Process,Protein Folding,Translational Control
Research Areas (Faceted)
cell_biology,metabolism,transcription_translation
Species
human
Target Sentence
CCT3 is also known as T complex protein 1 subunit gamma (TCP1-gamma) and is a molecular chaperone that assists in the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex, CCT3 may play a role in the assembly of BBSome, a complex involved in ciliogenesis and regulating the transport of vesicles to the cilia. CCT3 is known to play a role, in vitro, in the folding of actin and tubulin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P49368].
UniGene ID
Hs.491494
UniProt ID (eCommerce)
P49368

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.