human CCL5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CCL5.
shADV-204464
Ad-h-CCL5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CCL5 (C-C motif chemokine ligand 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
Description (Vector)
CCL5 is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
Gene ID
6352
Gene Name (Vector)
C-C motif chemokine ligand 5
Gene Symbol
CCL5
HGNC ID
HGNC:10632
ORF Size (aa)
276
RefSeq ID
NM_002985
RefSeq Synonyms
NM_002985, NM_001278736, BC008600,
Species
human
UniGene ID
Hs.514821
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.