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human CCDC50 shRNA silencing Adenovirus

Name 
Ad-h-CCDC50-shRNA
Cat No 
shADV-204329
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CCDC50.

shADV-204329
Ad-h-CCDC50-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CCDC50 (coiled-coil domain containing 50). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C3orf6; coiled-coil domain-containing protein 50; DFNA44; protein Ymer; YMER
Description (eCommerce)
Ymer was identified in a mass spectrometric study of epidermal growth factor signaling. It is a cytoplasmic tyrosine-phosphorylated protein that bears multiple ubiquitin-interacting domains. Recently Ymer has been implicated as a negative regulator of the NF-kappaB signaling pathway. Mutations in the gene that encodes Ymer, CCDC50, are the cause of autosomal dominant non-syndromic sensorineural deafness type 44.
Description (Vector)
CCDC50 encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
152137
Gene Name (eCommerce)
coiled-coil domain containing 50
Gene Name (Vector)
coiled-coil domain containing 50
Gene Symbol
CCDC50
HGNC ID
HGNC:18111
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
921
ORF Size (bp)
921 bp
Protein Name (eCommerce)
Coiled-coil domain-containing protein 50
RefSeq ID
NM_174908
RefSeq Synonyms
NM_178335, NM_174908, BC065004,
Research Areas
EGFR Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
Ymer was identified in a mass spectrometric study of epidermal growth factor signaling. It is a cytoplasmic tyrosine-phosphorylated protein that bears multiple ubiquitin-interacting domains. Recently Ymer has been implicated as a negative regulator of the NF-kappaB signaling pathway. Mutations in the gene that encodes Ymer, CCDC50, are the cause of autosomal dominant non-syndromic sensorineural deafness type 44.
UniGene ID
Hs.478682
UniProt ID (eCommerce)
Q8IVM0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.