human MCU shRNA silencing Adenovirus

Name 
Ad-h-MCU-shRNA
Cat No 
shADV-204228
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MCU.

shADV-204228
Ad-h-MCU-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MCU (mitochondrial calcium uniporter). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C10orf42;calcium uniporter protein, mitochondrial;CCDC109A;coiled-coil domain-containing protein 109A;HsMCU
Description (eCommerce)
MCU is a channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix. MCU is involved in several processes, including cellular response to calcium ion starvation, positive regulation of mitochondrial calcium ion concentration, and positive regulation of mitochondrial fission. [taken from NCBI Entrez Gene (Gene ID: 90550)].
Description (Vector)
MCU encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
Gene ID
90550
Gene Name (eCommerce)
mitochondrial calcium uniporter
Gene Name (Vector)
mitochondrial calcium uniporter
Gene Symbol
MCU
HGNC ID
HGNC:23526
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
Protein Name (eCommerce)
Calcium uniporter protein, mitochondrial
RefSeq ID
NM_138357
RefSeq Synonyms
NM_138357, NM_001270680, NM_001270679, BC034235,
Research Areas (Faceted)
cell_biology
Species
human
UniGene ID
Hs.591366
UniProt ID (eCommerce)
Q8NE86

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.