human CBX3 shRNA silencing Adenovirus

Name 
Ad-h-CBX3-shRNA
Cat No 
shADV-204198
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CBX3.

shADV-204198
Ad-h-CBX3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CBX3 (chromobox 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
chromobox homolog 3 (HP1 gamma homolog, Drosophila); chromobox protein homolog 3; HECH; heterochromatin protein 1 homolog gamma; heterochromatin protein HP1 gamma; heterochromatin-like protein 1; HP1 gamma; HP1 gamma homolog; HP1-GAMMA; HP1Hs-gamma; modifier 2 protein
Description (eCommerce)
CBX3 (chromobox protein homolog 3), also known as HP1gamma (heterochromatin protein 1 homolog gamma), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.
Description (Vector)
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Gene ID
11335
Gene Name (eCommerce)
chromobox 3
Gene Name (Vector)
chromobox 3
Gene Symbol
CBX3
HGNC ID
HGNC:1553
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
552
ORF Size (bp)
552 bp
Protein Name (eCommerce)
Chromobox protein homolog 3
RefSeq ID
NM_007276
RefSeq Synonyms
NM_016587, NM_007276, BC000954,
Research Areas
Cell Cycle,Chromatin Remodeling,Complexome,Gene Expression,Polycomb Proteins,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,transcription_translation,genetics
Species
human
Target Sentence
CBX3 (chromobox protein homolog 3), also known as HP1gamma (heterochromatin protein 1 homolog gamma), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.
UniGene ID
Hs.381189
UniProt ID (eCommerce)
Q13185

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.