human CAMKK2 shRNA silencing Adenovirus

Name
Ad-h-CAMKK2-shRNA

Cat No
shADV-204005

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human CAMKK2.

shADV-204005

Ad-h-CAMKK2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

calcium/calmodulin-dependent protein kinase beta; calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; caM-kinase kinase 2; caM-kinase kinase beta; CAMKK; CaMKK 2; caM-KK 2; CaMKK beta; caM-KK beta; CAMKK beta protein; CAMKKB

Description (eCommerce)

Calcium/calmodulin-dependent protein kinase kinase 2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of the CAMKK2 gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation [taken from NCBI Entrez Gene (Gene ID: 10645)].

Description (Vector)

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.

Gene ID

10645

Gene Name (eCommerce)

calcium/calmodulin dependent protein kinase kinase 2

Gene Name (Vector)

calcium/calmodulin dependent protein kinase kinase 2

Gene Symbol

CAMKK2

HGNC ID

HGNC:1470

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1626

ORF Size (bp)

1626 bp

Protein Name (eCommerce)

Calcium/calmodulin-dependent protein kinase kinase 2

RefSeq ID

NM_153499

RefSeq Synonyms

NM_172226, NM_172216, NM_172215, NM_172214, NM_153500, NM_153499, NM_006549, NM_001270486, NM_001270485, BC026060,

Research Areas

Cardiac Hypertrophy,Cardiology,Cardiovascular,Gene Expression,Kinase/Phosphatase,MAPK Signaling,Signal Transduction,Transcription Factor/Regulator,VEGF Signaling

Research Areas (Faceted)

cardiovascular,cell_biology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.297343

UniProt ID (eCommerce)

Q96RR4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.