human C7ORF23 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DMTF1.
shADV-203648
Ad-h-C7ORF23-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DMTF1 (cyclin D binding myb like transcription factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DMP1; DMTF; hDMP1; MRUL
Description (Vector)
DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. DMTF1 is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9988
Gene Name (Vector)
cyclin D binding myb like transcription factor 1
Gene Symbol
DMTF1
HGNC ID
HGNC:14603
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
RefSeq ID
NM_021145
RefSeq Synonyms
NM_021145, NM_001142327, NM_001142326, BC070064,
Species
human
UniGene ID
Hs.196129
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.