human C14ORF133 shRNA silencing Adenovirus

Name 
Ad-h-C14ORF133-shRNA
Cat No 
shADV-202632
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human VIPAS39.

shADV-202632
Ad-h-C14ORF133-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C14orf133; hSPE-39; SPE39; SPE-39; spermatogenesis-defective protein 39 homolog; VIPAR; VPS16B; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; VPS33B-interacting protein involved in polarity and apical protein restriction
Description (eCommerce)
VPS33B-interacting protein (VIPAR) plays a role in lysosomal trafficking. VIPAR may play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. VIPAR is also involved in direct or indirect transcriptional regulation of E-cadherin. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H9C1].
Description (Vector)
VIPAS39 encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.
Gene ID
63894
Gene Name (eCommerce)
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Gene Name (Vector)
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Gene Symbol
VIPAS39
HGNC ID
HGNC:20347
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
Spermatogenesis-defective protein 39 homolog
RefSeq ID
NM_022067
RefSeq Synonyms
NM_022067, NM_001193317, NM_001193316, NM_001193315, NM_001193314, BC015054,
Research Areas
Lysosomal Transport,Spermatogenesis,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,transcription_translation
Species
human
Target Sentence
VPS33B-interacting protein (VIPAR) plays a role in lysosomal trafficking. VIPAR may play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. VIPAR is also involved in direct or indirect transcriptional regulation of E-cadherin. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H9C1].
UniGene ID
Hs.16157
UniProt ID (eCommerce)
Q9H9C1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.