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human BRWD1 shRNA silencing Adenovirus

Name 
Ad-h-BRWD1-shRNA
Cat No 
shADV-202291
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human BRWD1.

shADV-202291
Ad-h-BRWD1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BRWD1 (bromodomain and WD repeat domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C21orf107; DCAF19; N143; WDR9
Description (Vector)
BRWD1 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. BRWD1 is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
Gene ID
54014
Gene Name (Vector)
bromodomain and WD repeat domain containing 1
Gene Symbol
BRWD1
HGNC ID
HGNC:12760
ORF Size (aa)
360
ORF Size (bp)
360 bp
RefSeq ID
NM_018963
RefSeq Synonyms
NM_033656, NM_018963, NM_001007246, BC140079,
Species
human
UniGene ID
Hs.654740

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.