human BNIP3 shRNA silencing Adenovirus

Name
Ad-h-BNIP3-shRNA

Cat No
shADV-202214

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human BNIP3.

shADV-202214

Ad-h-BNIP3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BNIP3 (BCL2 interacting protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

NIP3

Description (Vector)

BNIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.

Gene ID

664

Gene Name (Vector)

BCL2 interacting protein 3

Gene Symbol

BNIP3

HGNC ID

HGNC:1084

ORF Size (aa)

585

ORF Size (bp)

585 bp

RefSeq ID

NM_004052

RefSeq Synonyms

NM_004052, BC021989,

Species

human

UniGene ID

Hs.144873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.