human BAT1 shRNA silencing Adenovirus

Name
Ad-h-BAT1-shRNA

Cat No
shADV-201975

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human DDX39B.

shADV-201975

Ad-h-BAT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DDX39B (DExD-box helicase 39B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

BAT1; D6S81E; UAP56

Description (Vector)

DDX39B encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. DDX39B belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.

Gene ID

7919

Gene Name (Vector)

DExD-box helicase 39B

Gene Symbol

DDX39B

HGNC ID

HGNC:13917

ORF Size (aa)

1287

ORF Size (bp)

1287 bp

RefSeq ID

NM_004640

RefSeq Synonyms

NM_080598, NM_004640, BC013006, BC000361,

Species

human

UniGene ID

Hs.254042

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.