human BAG4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BAG4.
shADV-201939
Ad-h-BAG4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BAG4 (BCL2 associated athanogene 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAG-4; SODD
Description (Vector)
BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Gene ID
9530
Gene Name (Vector)
BCL2 associated athanogene 4
Gene Symbol
BAG4
HGNC ID
HGNC:940
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
RefSeq ID
NM_004874
RefSeq Synonyms
NM_004874, NM_001204878, BC038505,
Species
human
UniGene ID
Hs.194726
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.