human BAG4 shRNA silencing AAV

Name
AAV-h-BAG4-shRNA

Cat No
shAAV-201939

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BAG4.

shAAV-201939

AAV-h-BAG4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BAG4 (BCL2 associated athanogene 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BAG-4; SODD

Description (Vector)

BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Gene ID

9530

Gene Name (Vector)

BCL2 associated athanogene 4

Gene Symbol

BAG4

HGNC ID

HGNC:940

ORF Size (aa)

1374

ORF Size (bp)

1374 bp

RefSeq ID

NM_004874

RefSeq Synonyms

NM_004874, NM_001204878, BC038505,

Species

human

UniGene ID

Hs.194726

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.