human BACE1 shRNA silencing Adenovirus

Name
Ad-h-BACE1-shRNA

Cat No
shADV-201929

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human BACE1.

shADV-201929

Ad-h-BACE1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BACE1 (beta-secretase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ASP2; BACE; HSPC104

Description (Vector)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene ID

23621

Gene Name (Vector)

beta-secretase 1

Gene Symbol

BACE1

HGNC ID

HGNC:933

ORF Size (aa)

1506

ORF Size (bp)

1506 bp

RefSeq ID

NM_012104

RefSeq Synonyms

NM_138973, NM_138972, NM_138971, NM_012104, NM_001207049, NM_001207048, BC065492, BC036084,

Species

human

UniGene ID

Hs.504003

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.