human AUP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AUP1.
shADV-201826
Ad-h-AUP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AUP1 (ancient ubiquitous protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ancient ubiquitous protein 1
Description (eCommerce)
Ancient ubiquitous protein 1 (AUP1) may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y679].
Description (Vector)
AUP1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. AUP1 overlaps the gene for mitochondrial serine protease 25.
Gene ID
550
Gene Name (eCommerce)
AUP1, lipid droplet regulating VLDL assembly factor
Gene Name (Vector)
ancient ubiquitous protein 1
Gene Symbol
AUP1
HGNC ID
HGNC:891
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
Protein Name (eCommerce)
Ancient ubiquitous protein 1
RefSeq ID
NM_181575
RefSeq Synonyms
NM_181575, BC033646, BC001658,
Research Areas
Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Ancient ubiquitous protein 1 (AUP1) may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y679].
UniGene ID
Hs.411480
UniProt ID (eCommerce)
Q9Y679
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.