Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human ATXN2 shRNA silencing Adenovirus

Name 
Ad-h-ATXN2-shRNA
Cat No 
shADV-201812
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ATXN2.

shADV-201812
Ad-h-ATXN2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ATXN2 (ataxin 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ataxin-2; ATX2; SCA2; spinocerebellar ataxia type 2 protein; TNRC13; trinucleotide repeat-containing gene 13 protein
Description (eCommerce)
Pentanucleotide repeat expansions in the ATX2/SCA2 gene have been linked to spinocerebellar ataxia, a disorder that is characterized by gait ataxia, cognitive development, and seizures. The function of the ATX2/SCA2 has not been determined.
Description (Vector)
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
Gene ID
6311
Gene Name (eCommerce)
ataxin 2
Gene Name (Vector)
ataxin 2
Gene Symbol
ATXN2
HGNC ID
HGNC:10555
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3021
ORF Size (bp)
3021 bp
Protein Name (eCommerce)
Ataxin-2
RefSeq ID
NM_002973
RefSeq Synonyms
NM_002973, NM_001310123, NM_001310121, BC114546,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,EGFR Signaling,Golgi Apparatus,Neurobiology,Neurodegeneration,Neurodevelopment,Parkinson's Disease,RNA Binding,RNA Processing,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
signal_transduction,neurobiology,cell_biology,signal_transduction,cell_biology,neurobiology,developmental_biology,genetics,transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Pentanucleotide repeat expansions in the ATX2/SCA2 gene have been linked to spinocerebellar ataxia, a disorder that is characterized by gait ataxia, cognitive development, and seizures. The function of the ATX2/SCA2 has not been determined.
UniGene ID
Hs.76253
UniProt ID (eCommerce)
Q99700

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.