human ATP6V1B1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ATP6V1B1.
shADV-201757
Ad-h-ATP6V1B1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ATP6V1B1 (ATPase H+ transporting V1 subunit B1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP6B1; RTA1B; VATB; VMA2; VPP3
Description (Vector)
ATP6V1B1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
Gene ID
525
Gene Name (Vector)
ATPase H+ transporting V1 subunit B1
Gene Symbol
ATP6V1B1
HGNC ID
HGNC:853
ORF Size (aa)
1542
ORF Size (bp)
1542 bp
RefSeq ID
NM_001692
RefSeq Synonyms
NM_001692, BC063411,
Species
human
UniGene ID
Hs.64173
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.