human ATP1A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ATP1A1.
shADV-201678
Ad-h-ATP1A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide; CMT2DD; Na(+)/K(+) ATPase alpha-1 subunit; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Na+/K+ ATPase 1; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide
Description (eCommerce)
Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). [taken from NCBI Entrez Gene (Gene ID: 476)].
Description (Vector)
ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
476
Gene Name (eCommerce)
ATPase Na+/K+ transporting subunit alpha 1
Gene Name (Vector)
ATPase Na+/K+ transporting subunit alpha 1
Gene Symbol
ATP1A1
HGNC ID
HGNC:799
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3072
ORF Size (bp)
3072 bp
Protein Name (eCommerce)
Sodium/potassium-transporting ATPase subunit alpha-1
RefSeq ID
NM_000701
RefSeq Synonyms
NM_001160234, NM_001160233, NM_000701, BC050359, BC003077,
Research Areas
Cardiology,Cardiovascular,EGFR Signaling,Golgi Apparatus,Immunology,Signal Transduction,T-cell Receptor Signaling,TSH Signaling
Research Areas (Faceted)
signal_transduction,cardiovascular,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). [taken from NCBI Entrez Gene (Gene ID: 476)].
UniGene ID
Hs.371889
UniProt ID (eCommerce)
P05023
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.