human ATN1 shRNA silencing Adenovirus

Name 
Ad-h-ATN1-shRNA
Cat No 
shADV-201655
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ATN1.

shADV-201655
Ad-h-ATN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ATN1 (atrophin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
atrophin-1; B37; D12S755E; dentatorubral-pallidoluysian atrophy protein; DRPLA; HRS; NOD
Description (eCommerce)
Atrophin 1 is an evolutionarily conserved transcriptional corepressor. Expansion of a polyglutamine (polyQ) repeat within the atrophin 1 protein results in dentatorubral-pallidoluysian atrophy (DRPLA), an autosomal dominant neurodegenerative disease.
Description (Vector)
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
Gene ID
1822
Gene Name (eCommerce)
atrophin 1
Gene Name (Vector)
atrophin 1
Gene Symbol
ATN1
HGNC ID
HGNC:3033
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3576
ORF Size (bp)
3576 bp
Protein Name (eCommerce)
Atrophin-1
RefSeq ID
NM_001940
RefSeq Synonyms
NM_001940, NM_001007026, BC051795,
Research Areas
Apoptosis,Epilepsy,Neurobiology,Neurodegeneration,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Atrophin 1 is an evolutionarily conserved transcriptional corepressor. Expansion of a polyglutamine (polyQ) repeat within the atrophin 1 protein results in dentatorubral-pallidoluysian atrophy (DRPLA), an autosomal dominant neurodegenerative disease.
UniGene ID
Hs.143766
UniProt ID (eCommerce)
P54259

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.