human ASPSCR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ASPSCR1.
shADV-201582
Ad-h-ASPSCR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ASPSCR1 (ASPSCR1, UBX domain containing tether for SLC2A4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
alveolar soft part sarcoma chromosomal region candidate gene 1 protein; alveolar soft part sarcoma chromosome region, candidate 1; alveolar soft part sarcoma locus; ASPCR1; ASPL; ASPS; RCC17; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17; renal papillary cell carcinoma protein 17; tether containing UBX domain for GLUT4; TUG; UBX domain protein 9; UBX domain-containing protein 9; UBXD9; UBXN9
Description (eCommerce)
The gene which encodes ASPL (alveolar soft part sarcoma locus) has been identified as a fusion partner of the transcription factor TFE3 in ASPS and renal cell carcinomas.
Description (Vector)
ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.
Gene ID
79058
Gene Name (eCommerce)
ASPSCR1, UBX domain containing tether for SLC2A4
Gene Name (Vector)
ASPSCR1, UBX domain containing tether for SLC2A4
Gene Symbol
ASPSCR1
HGNC ID
HGNC:13825
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1047
ORF Size (bp)
1047 bp
Protein Name (eCommerce)
Tether containing UBX domain for GLUT4
RefSeq ID
NM_024083
RefSeq Synonyms
NM_024083, NM_001330528, NM_001251888, BC018722, BC006152,
Research Areas
Cancer,Transcriptional Misregulation in Cancer,Transport,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cancer,transcription_translation,cell_biology,cancer,transcription_translation
Species
human
Target Sentence
The gene which encodes ASPL (alveolar soft part sarcoma locus) has been identified as a fusion partner of the transcription factor TFE3 in ASPS and renal cell carcinomas.
UniGene ID
Hs.298351
UniProt ID (eCommerce)
Q9BZE9
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.